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Metal‐Free Dearomatization: Direct Access to Spiroindol(en)ines in Batch and Continuous‐Flow

The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Gerardo M. Ojeda Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), , 3001 Leuven, Belgium Center for Natural Products Research, Faculty of Chemistry, University of Havana, ZapatayG, 10400 Havana, CubaSearch for more papers…

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.

Gerardo M. Ojeda

Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), , 3001 Leuven, Belgium

Center for Natural Products Research, Faculty of Chemistry, University of Havana, ZapatayG, 10400 Havana, Cuba

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First published: 25 January 2019

Abstract

Sustainable chemistry always seeks new synthetic tools. This study brings into light new catalytic properties of triphenylphosphine with the following features: fast, inexpensive, and broad applicability towards dearomative spirocyclizations. Triphenylphosphine has been applied for the synthesis of complex spiro(hetero)cycles in batch and employing continuous flow, a field largely dominated by transition metals. In the cover image, triphenylphosphine has been shown to act as a bridge between sustainable chemistry and the synthesis of complex heterocycles. More information can be found in the Communication by U. K. Sharma, E. V. Van der Eycken et al. on page 2442.

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